AB1568 ENTHESITIC INVOLVEMENT IN PATIENTS WITH SAPHO SYNDROME. ULTRASOUND EVALUATION USING THE MASEI INDEX

Background SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare disease with prevalence of less than 1 in 10,000 [1]. Among its musculoskeletal manifestations, enthesis involvement has been observed, which, along the axial led many authors to consider it as part spondyloarthropathies group diseases. Ultrasound assessment known be more sensitive specific physical examination. The Madrid Sonographic Enthesitis Index (MASEI) one most widely used tools for evaluation [2]. It examines six entheses (quadriceps, proximal distal patellar, Achilles, plantar fascia, triceps) assesses possible elementary lesions defined by OMERACT [3], plus Doppler. This allows both inflammatory activity structural damage (structure, thickness, erosions, calcifications, bursitis) [4]. While there have some ultrasound studies on enthesic SAPHO, demonstrating even asymptomatic patients [5], currently no validated index this disease. Objectives aim study describe findings Syndrome patients’ using MASEI index. Methods descriptive, cross-sectional, single-center study, carried out Rheumatology Service Ramón y Cajal Hospital (Madrid, Spain). A convenience sampling was out, including all under active follow-up our clinics. Results 12 were included (83.3% women), mean age 52.41 (±9.4) years at time study. 66.7% smokers, 25% ex-smokers. BMI 26.62 (±5.69). average number painful 0.92 (±1.24) swollen found. had diagnosed previous clinical enthesitis. 38.5% positive score (>18). 20.42 (±11.02). Of score, only 2 (±1.5) found Doppler study; while 18.25 (±14.50) corresponded damage. within different explored described Table 1. greatest patellar (6.58 ± 3.75) (Figure 1). entheses. Enthesis Triceps Quadriceps Proximal Distal Achilles Plantar fascia Mean (±SD ) 1,58 ±2,392 2,75 ±3,467 3,75 ±3,166 6,58 ±3,753 3,25 ±2,667 2,5 ±2,780 R 0,5 ±0,52 L 1,08 ±2,06 1,33 ±1,83 1,42 ±1,73 ±1,76 1,75 ±1,91 2,17 ±1,03 4,42 ±3,09 1,50 ±1,09 1,25 ±1,60 Figure examination tendon. Conclusion hospital entheseal abnormalities results revealed clear predominance over presence lesions. Further larger sample size are necessary fully comprehend syndrome. References [1]Nguyen MT, Borchers A, Selmi C, Naguwa SM, Cheema G, Gershwin ME. Syndrome. Semin Arthritis Rheum. de diciembre 2012;42(3):254-65. [2]M. Cristina Mata Arnaiz, Eugenio Miguel Mendieta. Utilidad la ecografía en evaluación las entesis periféricas espondiloartritis. Reumatología Clínica. Volume 10, Issue 2, 2014, Pages 113-119. [3]De E, Cobo T, Muñoz-Fernández S, Naredo Uson J, Acebes JC, et al. Validity spondylarthropathy. Ann Rheum Dis. 2009;68:169–74. [4]Macía-Villa Falcao Medina De E. Ultrasonography psoriatic arthritis: descriptive reliability analysis elemental power subtypes. Scand J Rheumatol. 2019 Nov;48(6):454-459. [5]Queiro, R, Alonso, Alperi, M Entheseal Clin Rheumatol 31, 913–919 (2012). Acknowledgements: NIL. Disclosure Interests África Andreu-Suárez Grant/research support from: Amgen, Boris Anthony Blanco Cáceres Speakers bureau: MSD, Novartis, Janssen, Lilly, Pfizer, Janssen.